Searchable abstracts of presentations at key conferences in endocrinology

Endocrine Abstracts

Published by BioScientifica

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ea0010p88 | Steroids to include Cushing's | SFE2005

Non-genomic effects of the glucocorticoid receptor - the effect of glucocorticoids on activation of c-src and PKB/Akt

Kayahara M , Berry A , Ray D

Glucocorticoids (Gc) are potent anti-inflammatory agents, but their clinical use is limited by their significant side effects. The effects of glucocorticoids are mediated by the cytosolic glucocorticoid receptor (GR), which regulates transcription by transactivation or transrepression. Independent of these genomic effects of the GR are other, very rapid non-genomic effects.The glucocorticoid receptor forms a complex with hsp90, FKBP51, FKBP52 and cyp40 i...
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ea0007p164 | Neuroendocrinology and behaviour | BES2004

Down-regulation of neurotrophin receptor expression limits the regenerative potential of injured CNS neurons

Brown E , Berry M , Logan A

The application of exogenous neurotrophins (NT) has been widely proposed as a therapeutic strategy for the recovery of regeneration in axotomised CNS neurons. Results from this approach have, however, been disappointing since limited regenerative responses are elicited, we suggest due to limited neurotrophin receptor (NTR) expression. NT exert their trophic effects by signalling through the Trk/p75 receptors. Adequate receptor expression levels must, therefore, be central to t...
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ea0006oc23 | Neuroendocrinology | SFE2003

Receptor Shedding: A Novel Mechanism for the Disinhibition of CNS Neuronal Growth

Ahmed Z , Dent R , Berry M , Logan A

The promiscuous low affinity neurotrophin co-receptor p75NTR, a member of the nerve tumor necrosis factor (TNF) receptor superfamily, mediates neuronal survival as well as death, and interacts with Trk receptors to increase their affinity for neurotrophins. Furthermore, p75NTR is the transmembrane signalling moiety which associates with the NOGO binding receptor for all CNC myelin-derived axon growth inhibitors in the injured CNS. We have shown in rats that intravitreal implan...
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ea0011p333 | Diabetes, metabolism and cardiovascular | ECE2006

Adult pancreatic islet progenitor cells exhibit plasticity in vitro

Leadbeater WE , Summerfield MR , Hill DJ , Berry M , Logan A

Adult progenitor cells exist in most adult tissues, their differentiation being primed by insult, repopulating damaged or dysfunctional tissue. Utilisation of resident progenitor cells has the potential to cure many diseases, including neurodegenerative disorders or diabetes which presently can only be managed. This potential is limited in the brain by constraints on endogenous progenitor cell mobilisation and by difficulties in progenitor cell harvesting for ex vivo ex...
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ea0010p26 | Cytokines, growth factors, growth and development | SFE2005

Ahmed Z , Mazibrada G , Dent R , Berry M , Logan A

Upon binding of myelin-derived axon growth inhibitory ligands to the Nogo receptor (NgR), a complex is formed with LINGO-1 and the low affinity neurotrophin receptor p75NTR, which initiates axon growth cone collapse via a Rho-A-mediated pathway. We reasoned that, after tumor necrosis factor-α converting enzyme (TACE) cleavage of p75NTR, which triggers the initiation of regulated intramembrane proteolysis (RIP), signalling of growth cone collap...
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ea0008go2 | (1) | SFE2004

siRNA-Mediated Knock Down of NgR, p75NTR and Rho-A Disinhibits Neurotrophin-Induced Dorsal Root Ganglia Neurite Outgrowth on CNS Myelin

Ahmed Z , Dent RG , Suggate EL , Berry M , Logan A

Central nervous system neurones are generally incapable of regenerating their axons after injury due to the limited availability of neurotrophins, the development of a glial scar, and the presence of multiple axon growth inhibitors. We therefore designed short interfering RNA (siRNA) sequences to knock down components of the inhibitory signalling cascade and tested their ability to disinhibit the growth of FGF2-stimulated dorsal root ganglia neurone (DRGN) neurites in the pres...
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ea0029s66.3 | HPA axis, stress metabolism and adaptation | ICEECE2012

Modulation of cortisol action

Jangani M. , Berry A. , Matthews L. , Farrow S. , Donn R. , Ray D.

Variation in glucocorticoid (Gc) sensitivity underlies metabolic disease, and affects therapeutic response in inflammation. Using an in-vitro screening approach we identify two new mechanisms capable of regulating Gc sensitivity.The first involves interferon induced factor 16 (IFI16). IFI16 potentiated both transactivation, and Gc repression of NFκB. IFI16 did not affect glucocorticoid receptor (GR) expression, ligand dependent repression of GR expr...
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ea0019p210 | Neuroendocrinology and behaviour | SFEBES2009

EGFR antagonists promote disinhibited retinal ganglion cell axon regeneration by a glial-dependent mechanism

Morrison K , Ahmed Z , Leadbeater W , Gonzalez AM , Berry M , Logan A

It was reported that the inhibition of central nervous system (CNS) axon growth is mediated by Ca2+-dependent phosphorylation of epidermal growth factor receptor (pEGFR) and that local administration of small molecule EGFR antagonists to optic nerve lesions promoted retinal ganglion cell (RGC) axon regeneration (Koprivica et al. 2005). This result was attributed to suppression of EGFR kinase, which neutralised the axonal growth inhibitory potency of CNS myeli...
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ea0008p24 | Cytokines and growth factors | SFE2004

Exploiting Phage Technology for Targeting Gene Delivery into the CNS

Gonzalez AM , Rayner J , Logan A , Larocca D , Berry M , Burg M , Baird A

Gene delivery to the CNS is undermined by the lack of suitable vectors capable of delivering genes with sufficient specificity, efficacy and safety. In previous studies we have shown that bacteriophage particles, which lack tropism for mammalian cells, can be genetically modified to display specific ligands that allow binding, internalisation and cell transduction of receptor-bearing target cells. Moreover, phage particles can be forced to evolve using combinatorial techniques...
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ea0008go1 | (1) | SFE2004

Exploiting Phage Technology for Targeting Gene Delivery into the CNS

Gonzalez AM , Rayner J , Logan A , Larocca D , Berry M , Burg M , Baird A

Gene delivery to the CNS is undermined by the lack of suitable vectors capable of delivering genes with sufficient specificity, efficacy and safety. In previous studies we have shown that bacteriophage particles, which lack tropism for mammalian cells, can be genetically modified to display specific ligands that allow binding, internalisation and cell transduction of receptor-bearing target cells. Moreover, phage particles can be forced to evolve using combinatorial techniques...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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